Impacto do uso de prebióticos e probióticos como medida terapêutica para a recuperação da microbiota em crianças com transtorno do espectro autista - revisão integrativa

Edlainny Araujo Ribeiro; Renata Rodrigues da Silva Quincór; Fernando Antonio Figueiredo Maciel

doi:10.22481/rsc.v20i1.12934

Authors

Edlainny Araujo Ribeiro Universidade Federal de São Paulo https://orcid.org/0000-0001-6935-3400
Renata Rodrigues da Silva Quincór Faculdade de Ensino Superior da Amazônia Reunida https://orcid.org/0009-0005-1039-9785
Fernando Antonio Figueiredo Maciel Faculdade de Ensino Superior da Amazônia Reunida https://orcid.org/0009-0000-8913-4643

DOI:

https://doi.org/10.22481/rsc.v20i1.12934

Abstract

O presente artigo apresenta como objetivo analisar o papel clínico do uso de prebióticos e probióticos no manejo de distúrbios gastrointestinais em pacientes com transtorno do espectro autista, bem como descrever as evidências acerca dos benefícios associados. Esta pesquisa consiste em uma revisão integrativa da literatura realizada por meio das bases de dados National Library of Medicine National Institutes of Health (PUBMED e Biblioteca Virtual em Saúde (BVS), publicadas no período de 2012 a 2022. Foram identificados 954 artigos inicialmente e 12 foram incluídos para a revisão. Os probióticos mais frequentes foram Lactobacillus e o Bifidobacteria longum, responsáveis por gerar melhora global dos sintomas gastrointestinais de constipação, dor abdominal e diarreia, e melhora do comportamento social do TEA. Esses probióticos agem a partir da produção de neurotransmissores incluindo dopamina, norepinefrina, serotonina, ácido 4-aminobutírico (GABA), acetilcolina e histamina, que podem modular os níveis de serotonina e dopamina no cérebro, regulando os sintomas de irritabilidade, estereotipia e hiperatividade associada ao TEA. Portanto, faz-se necessária a realização de ensaios clínicos de longa duração a fim de avaliar o impacto do uso de probióticos e prebióticos para as sintomatologias geradas pelo TEA, podendo contribuir para melhora da qualidade de vida desses pacientes.

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