BROMELAÍNA COMO TERAPÊUTICA SUPLEMENTAR SEGURA EM DOENÇAS REUMÁTICAS: UMA REVISÃO SISTEMÁTICA

Raí Novaes Nogueira

doi:10.22481/rsc.v21i4.18306

Authors

Raí Novaes Nogueira Universidade Estadual do Sudoeste da Bahia

DOI:

https://doi.org/10.22481/rsc.v21i4.18306

Abstract

Objectives: Bromelain is an extract from the pineapple plant, used to treat neuropsychiatric diseases, including depressive disorder, with anti-inflammatory and analgesic properties. It can be used as an adjuvant treatment in some inflammatory rheumatological conditions, such as osteoarthritis.

Methods: Articles on bromelain and rheumatological diseases were searched in the PubMed and Embase databases between January 1965 and October 2024.

Results: Six articles on the topic were found, and a total of 2,418 patients were analyzed. The age ranged from 41 to 63 years, and females represented the majority in the studies, accounting for 54% to 88%. Bromelain dosage ranged from 45 mg to 800 mg/day. Five articles addressed osteoarthritis (n=279 patients); One study included several rheumatic diseases (joint, spinal, fibromyalgia, and soft tissue rheumatic diseases) with 2,139 patients. Only four (67%) of these articles demonstrated improvement in the various parameters evaluated, such as sensitivity, pain intensity, joint swelling, quality of life, and Lequesne score. Furthermore, in 3/6 (50%) of the articles, bromelain showed that it can provide an alternative treatment to anti-inflammatory drugs (NSAIDs). Side effects were described in 2/6 of the studies and were identical to those in the control groups. In 2/6 of the evaluated articles, they were absent; in 2/6, they were not defined in the text.

Conclusion: This review demonstrates that bromelain is a promising and safe therapy for osteoarthritis. However, the data need to be replicated in future, more comprehensive studies, including other rheumatic conditions.

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