Potencial antineoplásico do mastruz: uma revisão integrativa sobre Dysphania ambrosioides no combate ao câncer

Maicon Gabriel VIEIRA; Anny Carolinny Tigre Almeida CHAVES; Laura Lima TURANI; Raphael Ferreira QUEIROZ

doi:10.22481/rsc.v22i1.17041

Authors

Maicon Gabriel VIEIRA Universidade Estadual do Sudoeste da Bahia https://orcid.org/0009-0002-8731-9454
Anny Carolinny Tigre Almeida CHAVES Universidade Estadual de Feira de Santana https://orcid.org/0000-0002-9290-7368
Laura Lima TURANI Universidade Estadual do Sudoeste da Bahia https://orcid.org/0009-0006-4406-8877
Raphael Ferreira QUEIROZ Universidade Estadual do Sudoeste da Bahia https://orcid.org/0000-0002-7757-4286

DOI:

https://doi.org/10.22481/rsc.v22i1.17041

Keywords:

Cancer, Dysphania ambrosioides, Antineoplastic agents, Alternative therapy, Natural products, Tumor resistance

Abstract

Cancer remains one of the leading causes of mortality worldwide, posing a significant challenge to increasing life expectancy. Antineoplastic agents are widely used in cancer treatment; however, their effectiveness is often hindered by cellular resistance and adverse side effects. Therefore, exploring new therapeutic strategies is crucial. This study investigated the scientific evidence regarding the antineoplastic potential of mastruz (Dysphania ambrosioides) as a medicinal plant. A systematic review was conducted across seven databases using the descriptors “Dysphania ambrosioides,” “Chenopodium ambrosioides,” “antineoplastic agents,” “neoplasm,” and “cancer.” Full-text articles were included without time restrictions, in Portuguese, English, and Spanish. The findings revealed that D. ambrosioides extract significantly inhibited the growth of both solid and ascitic Ehrlich tumors and human leukemia cell lines (HL-60, BALL-1, K562, Nalm6, and RAJI), displaying an extremely low IC₅₀ (1 µg/ml) compared to doxorubicin (IC₅₀of 13.2 µg/ml), a commonly used chemotherapeutic drug. However, the extract did not inhibit the growth of hepatocarcinoma, cervical carcinoma, or acute B lymphoblastic leukemia cells. Despite these promising findings, clinical studies are required to validate the therapeutic potential of D. ambrosioides in cancer treatment.

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