Síntese total de α-pironas de ocorrência natural: uma revisão

Marcílio Wagner Fonte Silva; Clécio Souza Ramos; João Rufino de Freitas Filho

doi:10.22481/exon.v14i2.20556

Authors

Marcílio Wagner Fonte Silva Universidade Federal Rural de Pernambuco
Clécio Souza Ramos Universidade Federal Rural de Pernambuco
João Rufino de Freitas Filho Universidade Federal Rural de Pernambuco

DOI:

https://doi.org/10.22481/exon.v14i2.20556

Keywords:

α-Pyrones, Bioactive compounds, Total synthesis

Abstract

Pyrones constitute a family of six-membered unsaturated cyclic compounds containing an oxygen atom. In view of chemical motifs, γ-pyrone is the vinylogous form of α-pyrone, which possesses a lactone. As a result, these ring systems share similar chemical properties. α-pyrones are isolated in natural compounds from microorganisms, plants and animals, with a diversity in structures and great biological potential. The development of routes for obtaining these molecules by organic synthesis assists the structural elucidation and pharmacological action of these molecules. This work surveys synthetic strategies for the protection of natural α-pyrones. The present review summarizes the recent progresses in the total synthesis of naturally occurring α-pyrones.

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