Hipertermia magnética como terapia oncológica de precisão: uma revisão crítica

Matheus Fernandes Muniz de Almeida; Simara Santos Campos; Luizdarcy de Matos Castro

doi:10.22481/rbba.v16i1.18632

Authors

Matheus Fernandes Muniz de Almeida Southwest Bahia State University https://orcid.org/0009-0009-3576-5381
Simara Santos Campos Southwest Bahia State University https://orcid.org/0000-0002-0616-2030
Luizdarcy de Matos Castro Universidade Estadual do Sudoeste da Bahia https://orcid.org/0000-0002-1922-5168

DOI:

https://doi.org/10.22481/rbba.v16i1.18632

Keywords:

nanomedicine, superparamagnetic nanoparticles, magnetic hyperthermia

Abstract

Cancer is a public health challenge, demanding effective therapeutic responses. Although traditional approaches—surgery, radiotherapy, and chemotherapy—remain cornerstones of oncology, they are often accompanied by high toxicity and tumor resistance. Given these limitations, interest in complementary therapies with greater selectivity and minimally invasive nature is intensifying. In this context, magnetic hyperthermia (MH) stands out as a technique based on increasing tumor temperature, causing cell lysis. The technique uses superparamagnetic nanoparticles capable of heating locally when subjected to an alternating magnetic field. Thus, this work seeks to critically review the literature, synthesizing findings from in vitro, in vivo, and clinical trials, as well as discussing the limitations that still hinder the consolidation of MH. To this end, a broad bibliographic review of research published in the last two decades was conducted. The results reveal that MH has high therapeutic potential, promoting significant regression and, in some animal models, even complete elimination of tumors. In clinical practice, its effects on glioblastomas show promising benefit. However, incorporation into clinical practice still depends on overcoming obstacles.

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Author Biographies

Matheus Fernandes Muniz de Almeida, Southwest Bahia State University

Estudante de graduação em física da Universidade Estadual do Sudoeste da Bahia.

Simara Santos Campos, Southwest Bahia State University

Doutorado em Física pela Universidade Federal de Sergipe. Professora plena da Universidade Estadual do Sudoeste da Bahia, onde também exerce a função de coordenadora do curso de Licenciatura em Física na modalidade de educação a distância.

Luizdarcy de Matos Castro, Universidade Estadual do Sudoeste da Bahia

The author holds a degree in Physics from the Federal University of Viçosa (1997), a master's degree in Physics from the Federal University of Minas Gerais (1999), and a doctorate in Physics from the same institution (2003). His solid academic background in Physics underpins a career focused on both research and teaching.

Currently, he is a full professor at the State University of Southwest Bahia, where he develops teaching, research, and academic advising activities. His professional work is marked by the integration of theoretical and applied aspects of Physics, with emphasis on the area of magnetic materials and their properties.

He has consolidated experience in topics related to magnetism, including the study of magnetic materials and the application of variational principles to physical problems. In parallel, he dedicates himself to science education, with an emphasis on the development and use of alternative and low-cost teaching materials, seeking to broaden access to and understanding of scientific concepts.

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